Reaction optimization and up-scaling is a major cost and time concern in the pharmaceutical and fine-chemical industry. Often, when a route has been developed and the reaction has to be scaled up for production, major issues arise such as heat control and mixing. Typically, process optimization steps are required for each scaling stage.

With the technology of Access2Flow, reactions are translated into full-continuous processes that can be optimized with our hardware and software and translated from low-volume reactors for low-cost optimization to much larger reactors, while maintaining reaction parameters and process properties.

Application Notes

No 1; Fast scale up of microreactor technology to production. The Paal-Knorr synthesis